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PDF Free Download – Book Name: STP Mathematics 2a, questions, answers and study guides. PDF File Stp.pdfWhat to Expect After Myeloproliferative Neoplasms Diagnosis: A Systematic Review.
Myeloproliferative neoplasms (MPNs) are a group of hematologic malignancies with high morbidity and mortality. Due to the complexity of their etiologies and manifestations, patients with MPNs often have multiple questions about their disease. We performed a systematic review of MPN-related outcomes and their impact on quality of life (QOL). A PubMed/MEDLINE search was done to identify all pertinent studies on myeloproliferative neoplasms diagnosis and outcome published from January 2003 to September 2018. Two investigators independently analyzed and critically appraised abstracts, followed by full-text review to identify appropriate literature for inclusion. We included 24 studies with a total of 1772 patients with MPN diagnosis (excluding essential thrombocythemia and chronic myeloproliferative neoplasms in the non-polycythemia vera subgroup). Our review results show that diagnosis is a significant stressor in patients with MPNs. Subsequent interventions, interventions during the course of the disease, and patient satisfaction with treatment were key domains of patient outcomes. Patient outcome domains of QOL at diagnosis did not significantly differ between the subgroups of MPNs, whereas patient outcome domains of QOL during the disease course and patient satisfaction with treatment were lower in MPNs with transformation to acute myeloid leukemia (AML) compared with MPNs without transformation. At diagnosis, an MPN-related stressor was the most important patient outcome domain in patients with MPNs. Quality of life domains in patients with
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