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26 mb) · · · · · Free download · 47.05 MB · Downloads: 36 · Downloads 2 · · · · · Creative Commons: Attribution-NonCommercial-ShareAlike 3.1ABSTRACT

Cancer is a leading cause of mortality worldwide. Lung cancer was found to be the most common type of cancer-related deaths (28.2%) in 2015. Lung cancer is still considered a great challenge for diagnosis and treatment despite recent advances in clinical science. In the course of cancer treatment, the chemotherapy drugs are the most frequently utilized drugs to control tumor growth. However, chemotherapy is often accompanied by major side effects. Some of these effects such as vomiting and hair loss are visible and measurable, whereas others are still not distinguishable. Therefore, the detection of chemotherapy-related adverse effects at earlier stage of treatment is of great importance for both patients and clinicians. In this study, we report a two-step method for detection of chemotherapy-induced hair loss from hair images collected by a smartphone. First, hair images of either control or experimental group (before and after chemotherapy) were collected by a smartphone and then the collected images were color and shape-modified using Microsoft Kinect. Second, feature sets for hair images were constructed using the image processing techniques including contrast-enhanced processing and multilayer perception (MLP) neural network. The experiments were performed on 50 sets of hair images of either control or experimental group. We showed that compared with any of the feature sets of hair images collected by smartphone, the MLP neural network approach could effectively discriminate between the control and experimental groups. The discrimination results were further verified with a partial least square (PLS) regression analysis. Based on the experiment results, we confirmed that our proposed methodology could detect chemotherapy-induced hair loss from hair images collected by a smartphone.Q:

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