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Maternal drug use and the effect on fetal growth is an important problem in maternal-fetal medicine. We have studied the association between maternal drug use and birth weight, length, and head circumference in newborn babies in a case-controlled study. Cord blood concentrations of cocaine were lower in cord blood specimens of babies born to mothers who used cocaine during pregnancy than in cord blood specimens of babies born to women who did not use cocaine during pregnancy. Cord blood concentrations of methadone were higher in the cocaine group than in the control group. Cord blood concentrations of both cocaine and methadone were significantly correlated with birth weight, and there was a trend toward association between birth weight and length and head circumference. These findings suggest that cocaine use during pregnancy leads to a decreased birth weight, whereas methadone use during pregnancy leads to a higher birth weight.***Background.***â*Candida* bloodstream infections have increased in US healthcare facilities. Fluconazole
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setCalendarMode(CalendarMode.US_CALENDAR);
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dismissPopupAnchor();
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@Override
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Being a photographer or a photo editor or an experinced picture collector is a very admirable job if youâre looking for a challenging and hard-earned vocation. Basically, being a self-employed professional photographer is a hard work and requires a lot of dedication. And when youâre looking for that, you need to prepare yourself for the bitter reality.Knockdown of LINC00176 suppresses cell proliferation and invasion and induces cell apoptosis in glioma cells.
LncRNAs are involved in various biological processes and have been reported as promising biomarkers in glioma. In the current study, we investigated the potential impact of lncRNA LINC00176 on glioma tumorigenesis. RT-qPCR was used to detect the expression of LINC00176 in 30 pairs of glioma tissues and normal brain tissues. The relationship between LINC00176 expression and overall survival was analyzed by Kaplan-Meier survival analysis. Glioma cell lines were transfected with a lentivirus containing LINC00176-specific small interfering RNA (siRNA) for further determination of its biological function. The effects of LINC00176 on cell proliferation, migration and invasion were assessed by MTT, wound healing and transwell assays. The results indicated that LINC00176 expression was significantly upregulated in glioma tissues compared to normal brain tissues. Kaplan-Meier survival analysis revealed that patients with higher LINC00176 expression had a significantly shorter overall survival. The results of the MTT and cell invasion assays revealed that LINC00176 knockdown significantly inhibited the proliferation, migration and invasion of glioma cells. Moreover, the results of the Western blot assays demonstrated that LINC00176 knockdown induced G2/M phase arrest and induced cell apoptosis in glioma cells. In conclusion, our study revealed that LINC00176 promoted the proliferation, migration and invasion of glioma cells. Therefore, LINC00176 may be a promising therapeutic target for glioma.Q:
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