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Microvillous inclusion disease: light and electron microscopic features of the reticuloendothelial system.
Seven non-immunosuppressed infants with clinically severe diarrhoea have been investigated during the course of their disease. Light and electron microscopic examination of the liver revealed the presence of large numbers of vacuoles containing dilated, irregularly shaped and electron-lucent cytoplasm in Kupffer cells. These cells had both phagocytosed and free in the cytoplasm, frequently enmeshed in a lymphocytic infiltrate. The proliferating trabecular liver was sclerosed and the sinusoids were distorted. The splenic red pulp was also reduced in number and size of sinusoids and it was resorbed by macrophages. These cells engulfed many of the smaller lymphocytes. The cytoplasm of macrophages was frequently found to contain swollen intracytoplasmic vesicles and occasional small vacuoles. The lymphocytes had degenerated and were frequently phagocytosed. These observations suggest a reticuloendothelial system abnormality similar to that seen in paraneoplastic thymic hyperplasia.Allogeneic and syngeneic hindquarter transplantation of the rat.
We examined the immunological compatibility of hindquarter allografts in the rat. Syngeneic hindquarter grafts survived in the first week after transplantation, while allogeneic hindquarter grafts were rejected within 7 days by allogeneic graft-host combinations. This was true whether the grafts were perfused or nonperfused. Autotransplantation of syngeneic hindquarter grafts in the same animal resulted in long-term survival. Endogenous splenic cytotoxicity against hindquarter grafts was detected in allogeneic recipients. Autotransplantation of hindquarter grafts increased the longevity of syngeneic hindquarter grafts. Therefore, the rat hindquarter allograft model is a useful technique for the study of immunologic tolerance.�I want to thank all of the wonderful people who have helped me create this book.” I couldn’t think of a better way to recognize the many volunteers, donors and colleagues who have helped the organization I love and work with the most.

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We describe the development and the psychometric properties of a self-reported computer use questionnaire in Spain, the Spanish Computer Use Questionnaire (SCUQ). This paper presents the psychometric properties of this new instrument: reliability, factor structure, internal consistency, construct validity, and concurrent validity. A Spanish version of the SCUQ was administered to a sample of 746 subjects (420 women, 326 men) that were recruited randomly. Exploratory and confirmatory factor analysis were conducted to test the factor structure of the questionnaire. Internal consistency of the SCUQ was assessed with Cronbach alpha. The concurrent validity of the questionnaire was assessed using Pearson’s correlation. Factor analysis showed that the questionnaire had 2 factors, which accounted for 75% of the variance: „Use computer for leisure and entertainment“ (52.3%) and „Use computer for productive purposes“ (28.3%). The internal consistency of the questionnaire was high. This study also showed that the SCUQ is an easy and accurate instrument for the assessment of computer use.Q:

How to connect to SQL Server Express instance using Entity Framework?

When connecting to a SQL Server Express instance using Entity Framework I cannot use SqlConnection.Open()
SqlConnection instance = new SqlConnection(„Data Source=localhost;Initial Catalog=MyDb;User Id=sa;Password=password“);
SqlCommand command = new SqlCommand(„SELECT * FROM TblName“, instance);
command.Connection.Open(); // Prorably should be a SqlConnection

This results in: „Cannot open a connection through the connection pool because the previous connection